An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains
نویسندگان
چکیده
منابع مشابه
Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
Although highly effective in the general population when well matched to circulating influenza virus strains, current influenza vaccines are limited in their utility due to the narrow breadth of protection they provide. The strain specificity of vaccines presently in use mirrors the exquisite specificity of the neutralizing antibodies that they induce, that is, antibodies which bind to the high...
متن کاملAn Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice
Currently licensed vaccines against the influenza A virus (IAV) need to be updated annually to match the constantly evolving antigenicity of the influenza virus glycoproteins, hemagglutinin (HA), and neuramidiase (NA). Attempts to develop universal vaccines that provide broad protection have resulted in some success. Herein, we have shown that a replication-deficient adenovirus expressing H5/M2...
متن کاملبیان و خالص سازی پروتئین کایمر نوترکیب (3M2e-HA2) واجد نواحی حفاظت شده هماگلوتینین و پروتئین ماتریکس ویروس آنفلوانزا در راستای تولید واکسن زیرواحدی جهانی
Background and purpose: Influenza virus is one of the most important respiratory infectious agents. Viral antigenic variations are major problems for vaccine production process. At present, many researches have focused on conserved domains of influenza virus antigenic peptides for subunit vaccine development. Hemagglutinin small subunit (HA2) and the 23 amino acid extracellular N-terminal domai...
متن کاملInfluenza virus hemagglutinin stalk-based antibodies and vaccines.
Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Because of the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies,...
متن کاملCloning, expression and purification of hemagglutinin conserved domain (HA2) of influenza A virus, to be used in broad-spectrum subunit vaccine cocktails
Introduction: Influenza virus has several conserved peptides which have the capacity to be used as suitable candidates for appropriate and stable vaccine production against different types of influenza viruses. One of these peptides is HA2, the hemagglutinin stalk domain which mediates the membrane fusion and is conserved amongst different sub-types of influenza virus. This peptide is a good ca...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2019
ISSN: 2076-393X
DOI: 10.3390/vaccines7030117